Exploring the interplay between cellular development and mechanics in the developing human brain

The human brain has a complex structure on both cellular and organ scales. This is closely related to the brain's abilities functions. Disruption of one biological processes occurring during development scale may affect cortical folding pattern scale. However, link between disruptions in associated malformation remains largely unknown. From mechanical perspective, forces generated lead instability and, eventually, mergence folds. To fully understand mechanism underlying malformations development, it key consider events that occur Here we present computational model describing division migration scale, as well growth tissue or continuous way by coupled finite advection-diffusion model. We introduce cell density an independent field controlling volumetric growth. Furthermore, formulate positive relation layer stiffness. allows us study influence velocity, diffusivity, local stiffness, connectivity cells process properties normal abnormal numerically. show how increase neurons increases layer's Moreover, weWe validate our simulation results through comparison with histological sections fetal brain. current aims be first step towards providing reliable platform systematically evaluate role different vice versa.